From Genomic Association to Causation: A Convergent Neuroscience Approach to Linking Levels of Analysis for Understanding Neuropsychiatric Disorders (U19 Clinical Trial Optional)

Department of Health and Human Services National Institutes of Health
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Research/project funding

Reference Number

RFA-MH-21-165

This Funding Opportunity Announcement (FOA) supports research to understand causal linkages across different scales (e.g., molecular, cellular, circuit, behavioral, clinical) relevant to neuropsychiatric disorders. The Convergent Neuroscience (CN) program goal is to establish theoretical models to show how specific constituent processes at one level of analysis contribute to quantifiable properties at other levels, either directly or as emergent phenomenon. Studies should incorporate four key features: (1) a premise on identifying the causal and disease-relevant relationships between objective genetic/biological/clinical criteria at two or more contiguous levels of analysis, whether involving human subjects or experimentally tractable in vivo or in vitro paradigms (genetic variation can be one of the contiguous levels of analysis or can be the context in which other, higher levels of analysis are linked); (2) use of the large and diverse datasets existing or generated at these levels of analysis to develop testable theoretical models within three years of award; (3) experimental testing of the model-based predictions to confirm or reject their validity, (4) preferential utilization of scalable approaches to maximize analytic throughput, content, sensitivity, selectivity, spatiotemporal resolution and robustness. Results should yield causal linkages between levels of analysis and mechanistically explain key functional dimension(s) relevant to mental illness pathophysiology. Leadership of research teams will include expertise in experimental neurobiology or clinical research paired with orthogonal theoretical disciplines (e.g., mathematics, computation, physics). This endeavor will be facilitated by active participation in a community-driven manner through the CN Consortium. Groups will manage their data and analysis methods using a harmonized framework with other U19 awardees through a CN Consortium Data Commons structure.
Categories: Health.

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Posted

Post Expires

Application Deadline

Type

Research/project funding

Reference Number

RFA-MH-21-165

United States